Organoids

Organoids

Overview

Overview

Recent strides in stem cell research have led to the development of organ-specific tissue from stem cells, particularly cerebral brain organoids. These miniature 3D cultures, derived from adult human blood, mimic the complexity of actual organs. They provide a valuable model for studying neurodevelopmental conditions like epilepsy. Although their current use in epilepsy research is limited, notable references in PubMed highlight their potential.


Ongoing advancements in organoid technology ensure reproducibility. Additionally, personalized medicine holds promise by creating organoids directly from affected individuals for drug testing, though automation is key for scalability (Reference: Kelava and Lancaster, 2016).

Recent strides in stem cell research have led to the development of organ-specific tissue from stem cells, particularly cerebral brain organoids. These miniature 3D cultures, derived from adult human blood, mimic the complexity of actual organs. They provide a valuable model for studying neurodevelopmental conditions like epilepsy. Although their current use in epilepsy research is limited, notable references in PubMed highlight their potential.


Ongoing advancements in organoid technology ensure reproducibility. Additionally, personalized medicine holds promise by creating organoids directly from affected individuals for drug testing, though automation is key for scalability (Reference: Kelava and Lancaster, 2016).

Cerebral Organoid

Cerebral Organoid

Guided Method: Unguided
Structures: Forebrain, Midbrain, Hindbrain
Cell Types: All cell types listed above
Diseases: Machado-Joseph disease

Guided Method: Unguided
Structures: Forebrain, Midbrain, Hindbrain
Cell Types: All cell types listed above
Diseases: Machado-Joseph disease

Forebrain Organoid

Forebrain Organoid

Guided Method: Guided
Structures: Cerebellum, Thalamus, Hypothalamus
Cell Types: Oligodendrocytes, Microglia, Astrocytes, basal radial glia
Diseases: Fragile X Syndrome, Alzheimers

Guided Method: Guided
Structures: Cerebellum, Thalamus, Hypothalamus
Cell Types: Oligodendrocytes, Microglia, Astrocytes, basal radial glia
Diseases: Fragile X Syndrome, Alzheimers

Cerebral Organoid

Guided Method: Unguided
Structures: Forebrain, Midbrain, Hindbrain
Cell Types: All cell types listed above
Diseases: Machado-Joseph disease

Forebrain Organoid

Guided Method: Guided
Structures: Cerebellum, Thalamus, Hypothalamus
Cell Types: Oligodendrocytes, Microglia, Astrocytes, basal radial glia
Diseases: Fragile X Syndrome, Alzheimers

Hindbrain Organoid

Guided Method: Guided
Structures: Pons, cerebellum and medulla
Cell Types: Purkinje Cells, Granule cells

Midbrain Organoid


Guided Method: Guided
Structures: Tectum, the cerebral aqueduct, the tegmentum, and the cerebral peduncles
Cell Types: Dopaminergic, GABAergic, Glutaminergic
Diseases: Parkinsons

Hindbrain Organoid

Hindbrain Organoid

Guided Method: Guided
Structures: Pons, cerebellum and medulla
Cell Types: Purkinje Cells, Granule cells

Midbrain Organoid

Midbrain Organoid

Guided Method: Guided
Structures: Tectum, the cerebral aqueduct, the tegmentum, and the cerebral peduncles
Cell Types: Dopaminergic, GABAergic, Glutaminergic
Diseases: Parkinsons

Guided Method: Guided
Structures: Tectum, the cerebral aqueduct, the tegmentum, and the cerebral peduncles
Cell Types: Dopaminergic, GABAergic, Glutaminergic
Diseases: Parkinsons